As with the dialogue, so with the slave-boy episode within it, two questions are handled, one of them substantive, the other a question of method. The substantive question is how to double the square of a side of 2 units; the procedural question is how, if at all, can an answer be found by one who does not know it. It develops that the answer must be sought exclusively among opinions which the boy already holds, by means of questioning. What (...) I want to argue is that the boy's lesson is not an unqualified success any more than is Meno's. I shall maintain that, exactly parallel to the main discussion, Plato means to cast suspicion on the substantive answer which Socrates and the boy arrive at, and for an exactly parallel reason: the inquiry has been conducted improperly. On the other hand the lesson is far from an unqualified failure, since despite its lack of substantive result, it contains an important message about method. Just as it becomes clear in the discussion with Meno that any disciplined inquiry into virtue must refrain from asking what virtue is like until it has settled the more fundamental question of what virtue itself is, so in the slave-boy passage it is learned that we must refrain from asking what the solution to our problem is like until we have settled on what the solution itself is. (shrink)

Malcolm S Justins; Fairness, Equality and Needs as Claims to Education, Journal of Philosophy of Education, Volume 4, Issue 1, 30 May 2006, Pages 121–137, https.

The concept of monophyly is central to much of modern biology. Despite many efforts over many years, important questions remain unanswered that relate both to the concept itself and to its various applications. This essay focuses primarily on four of these: i) Is it possible to define monophyly operationally, specifically with respect to both the structures of genomes and at the levels of the highest phylogenetic categories (kingdoms, phyla, classes)? ii) May the mosaic and chimeric structures of genomes be sufficiently (...) important factors in phylogeny that situations exist in which the concept may not be applicable? iii) In the history of life on earth were there important groups of organisms that probably had polyphyletic, rather than monophyletic, origins? iv) Does the near universal search for monophyletic origins of clades lead, on occasion, to both undesirable narrowing of acceptable options for development of evolutionary scenarios and sometimes actual omission from consideration of less conventional types of both data and modes of thought, possibly at the expense of biological understanding? Three sections in the essay consider possible answers to these questions: i) A reassessment is made of major features of both the concept and some of its applications. Recent research results make it seem improbable that there could have been single basal forms for many of the highest categories of evolutionary differentiation (kingdoms, phyla, classes). The universal tree of life probably had many roots. Facts contributing to this perception include the phylogenetically widespread occurrences of: horizontal transfers of plasmids, viral genomes, and transposons; multiple genomic duplications; the existence and properties of large numbers of gene families and protein families; multiple symbioses; broad-scale hybridizations; and multiple homoplasys. Next, justifications are reassessed for the application of monophyletic frameworks to two major evolutionary developments usually interpreted as having been monophyletic: ii) the origins of life; and iii) the origins of the vertebrate tetrapods. For both cases polyphyletic hypotheses are suggested as more probable than monophyletic hypotheses. Major conclusions are, as answers to the four questions posed above: probably not, yes, yes, and yes. (shrink)

It has long been unclear as to why particular cancers preferentially metastasize to certain sites. The possibilities usually discussed involve differential survival and proliferation at these sites, or selective trapping with or without preferential homing. A recent report by Muller et al.(1) provides evidence for preferential homing of breast cancer to metastatic sites. The findings indicate that the chemokine receptors CXCR4 and CCR7 are found on breast cancer cells and their ligands are highly expressed at sites associated with breast cancer (...) metastases. This results in chemotaxis, or directed migration of tumor cells from their primary site via the circulation to the preferential sites of metastases. The evidence for this model and its significance are reviewed here. BioEssays 23:674–676, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Summary The common view has been that Darwin regarded species as artificial and arbitrary constructions of taxonomists, not as distinct natural units. However, in his transmutation notebooks he clearly subscribed to the reality of species, on the basis of the criterion of non-interbreeding. A consequence of this biological species concept was his identification of the acquisition of reproductive isolation as the mark of the completion of speciation. He developed in the notebooks a theory of geographic speciation on the grounds of (...) (a) an empirical correlation between barriers and the geographical distributions of allied species, (b) the analogy of artificial isolation in the formation of new domesticated varieties, and (c) the logical consequence of blending inheritance. A brief discussion of Darwin's species concept in later writings concludes the paper. (shrink)

Drug Safety Communications are used by the Food and Drug Administration to inform health care providers, patients, caregivers, and the general public about safety issues related to FDA-approved drugs. To assess patient knowledge of the messaging contained in DSCs related to the sleep aids zolpidem and eszopiclone, we conducted a large, cross-sectional patient survey of 1,982 commercially insured patients selected by stratified random sampling from the Optum Research Database who had filled at least two prescriptions for either zolpidem or eszopiclone (...) between July 1, 2012 and June 30, 2013. Among the 594 respondents, two-thirds reported hearing generally about drug safety information prior to starting a new drug, with the remaining one-third “rarely” or “never” hearing such information. Providers and pharmacists were primary sources of drug safety information. Two-thirds of zolpidem users and half of eszopiclone users reported having heard about the related DSC messages, ability to accurately identify the major factual messages was limited. Respondents reacted to new drug safety information about their sleep aids by reporting that they would want to learn about alternative ways to help them sleep and seek out more information about the safety of their specific sleeping pill. Opportunities may exist for the FDA to work with providers and pharmacies to help ensure the DSC information is more widely received and is more fully understood by those taking the affected medications. (shrink)

Sober (1984) has considered the problem of determining the evidential support, in terms of likelihood, for a hypothesis that is incomplete in the sense of not providing a unique probability function over the event space in its domain. Causal hypotheses are typically like this because they do not specify the probability of their initial conditions. Sober's (1984) solution to this problem does not work, as will be shown by examining his own biological examples of common cause explanation. The proposed solution (...) will lead to the conclusion, contra Sober, that common cause hypotheses explain statistical correlations and not matchings between event tokens. (shrink)

Given its brevity, Plato's Meno covers an astonishingly wide array of topics: politics, education, virtue, definition, philosophical method, mathematics, the nature and acquisition of knowledge and immortality. Its treatment of these, though profound, is tantalisingly short, leaving the reader with many unresolved questions. This book confronts the dialogue's many enigmas and attempts to solve them in a way that is both lucid and sympathetic to Plato's philosophy. Reading the dialogue as a whole, it explains how different arguments are related to (...) one another and how the interplay between characters is connected to the philosophical content of the work. In a new departure, this book's exploration focuses primarily on the content and coherence of the dialogue in its own right and not merely in the context of other dialogues, making it required reading for all students of Plato, be they from the world of classics or philosophy. (shrink)

Hugo de Vries claimed that he had discovered Mendel's laws before he found Mendel's paper. De Vries's first ratios, published in 1897, for the second generation of hybrids were 2/3:1/3 and 80%:20%. By 1900, both of these ratios had become 3:1. These changing ratios suggest that as late as 1897 de Vries had not discovered the laws, although he asserted, from 1900 on, that he had found the laws in 1896. An Appendix details de Vries's Mendelian experiments as described in (...) the original edition of volume two of Die Mutationstheorie, but omitted entirely from the English translation. (shrink)

First published in 1989, this book tackles a relatively little-explored area of Wittgenstein’s work, his philosophy of psychology, which played an important part in his late philosophy. Writing with clarity and insight, Budd traces the complexities of Wittgenstein’s thought, and provides a detailed picture of his views on psychological concepts. A useful guide to the writings of Wittgenstein, the book will be of value to anyone concerned with his work as a whole, as well as those with a more general (...) interest in the philosophy of psychology. (shrink)

This book presents the first comprehensive treatment of Aristotle's theory of autonomous scientificdisciplines and the systematic connections between them: analogy, focality, and cumulation.

In the first full-length study in any modern language dedicated to the Meteorologica, Malcolm Wilson presents a groundbreaking interpretation of Aristotle's natural philosophy. Divided into two parts, the book first addresses general philosophical and scientific issues by placing the treatise in a diachronic frame comprising Aristotle's predecessors and in a synchronic frame comprising his other physical works. It argues that Aristotle thought of meteorological phenomena as intermediary or 'dualizing' between the cosmos as a whole and the manifold world of (...) terrestrial animals. Engaging with the best current literature on Aristotle's theories of science and metaphysics, Wilson focuses on issues of aetiology, teleology and the structure and unity of science. The second half of the book illustrates Aristotle's principal concerns in a section-by-section treatment of the meteorological phenomena and provides solutions to many of the problems that have been raised since the time of the ancient commentators. (shrink)

In this paper I shall approach Hesiod's poetry from two, rather different, directions; consequently, the paper itself falls into two parts, the argument and conclusions of which are largely independent. In I offer some observations on the vexed question of the organisation of Works and Days; that is, my concern is with the coherence of the poem's form and content. In my attention shifts to the function of this poem and of its companion, Theogony; given the form and content of (...) these two poems, what can we plausibly conjecture about the end or ends to which they were composed? In particular, I shall consider whether, and in what sense, these poems may be regarded as didactic in intent. Much of what I have to say in I say with a measure of confidence; in , by contrast, my primary aim is to undermine unwarranted confidence — although I do, even here, reach some positive conclusions. (shrink)

Freedom and the Rule of Law takes a critical look at the historical beginnings of law in the United States, and how that history has influenced current trends regarding law and freedom. Anthony Peacock has compiled articles that examine the relationship between freedom and the rule of law in America. The rule of law is fundamental to all liberal constitutional regimes whose political orders recognize the equal natural rights of all.

This introduction brings to life the main themes in Indian philosophy of language by using an accessible translation of an Indian classical text to provide an entry into the world of Indian linguistic theories. -/- Malcolm Keating draws on Mukula's Fundamentals of the Communicative Function to show the ability of language to convey a wide range of meanings and introduce ideas about testimony, pragmatics, and religious implications. Along with a complete translation of this foundational text, Keating also provides: - (...) Clear explanations of themes such as reference, figuration and sentence meaning - Commentary illuminating connections between Mukula and contemporary philosophy - Romanized text of the Sanskrit - A glossary of terms and annotated bibliography - A chronology of important figures and dates -/- By complementing a historically-informed introduction with a focused study of an influential primary text, Keating responds to the need for a reliable guide to better understand theories of language and related issues in Indian philosophy. (shrink)

Malcolm Jones; Innate Powers, Concepts and Knowledge: a critique of D. W. Hamlyn's account of concept possession, Journal of Philosophy of Education, Volume 15.

Erdelyi's argument for integrating clinical data on repression, mainly Freudian, with laboratory findings suffers from logical and factual errors concerning Freudian repression and about experiments on forgetting.

_The Athiest’s Primer_ is a concise but wide-ranging introduction to a variety of arguments, concepts, and issues pertaining to belief in God. In lucid and engaging prose, Malcom Murray offers a penetrating yet fair-minded critique of the traditional arguments for the existence of God. He then explores a number of other important issues relevant to religious belief, such as the problem of suffering and the relationship between religion and morality, in each case arguing that atheism is preferable to theism. The (...) book will appeal to both students and professionals in the philosophy of religion, as well as general audiences interested in the topic. (shrink)

Human beings, like chimpanzees, deliberately kill their own species in order to expand their territory. For a self-aware social animal to attack its own kind, it would need to evolve a mechanism to dehumanize, or “dechimpanzee-ize” those it attacks. It is suggested that cruelty reflects such an evolved predisposition. The implications for violence prevention are discussed.

A simple numerical procedure is presented for the problem of estimating the parameters of models for the distribution of eggs oviposited in a host. The modelling is extended to incorporate both host density and time dependence to produce a remarkably parsimonious structure with only seven parameters to describe a data set of over 3,000 observations. This is further refined using a mixed model to accommodate several large outliers. Both models show that the level of superparasitism declines with increasing host density, (...) and the rate declines over time. It is proposed that the differing behaviours represented by the mixed model may reflect a balance between behavioural strategies of different selective benefit. (shrink)

Malcolm David Eckel takes us on a contemporary quest to discover the essential meaning behind the Buddha's many representations. Eckel's bold thesis proposes that the proper understanding of Buddhist philosophy must be thoroughly religious--an understanding revealed in Eckel's new translation of the philospher Bhavaviveka's major work, The Flame of Reason. Eckel shows that the dimensions of early Indian Buddhism--popular art, conventional piety, and critical philosophy--all work together to express the same religious yearning for the fullness of emptiness that Buddha (...) conveys. (shrink)

Wittgenstein was one of the most powerful influences on contemporary philosophy, yet he shunned publicity and was essentially a private man. This remarkable, vivid, personal memoir is written by one of his friends, the eminent philosopher Norman Malcolm. Reissued in paperback, this edition includes the complete text of fifty-seven letters which Wittgenstein wrote to Malcolm over a period of eleven years. Also included is a concise biographical sketch by another of Wittgenstein's philosopher friends, Georg Henrik von Wright. 'A (...) reader does not need to care about philosophy to be excited by Mr Malcolm's book; it is about Wittgenstein as a man, and its interest is human interest'. (shrink)

My response consists essentially of an attempt to throw light on Peacocke's basic proposal as to how musical expressiveness should be understood by a comparison and contrast with a somewhat similar suggestion of mine.

Discusses the translation of Hobbes's De cive, which was published in England in 1651 under the title Philosophicall Rudiments. A few surviving copies include a dedicatory epistle by the translator, signed ‘C. C.’ In this essay, evidence is presented for identifying this translator with the young poet Charles Cotton. His indirect connections with both Hobbes and Lady Fane are explored, and attention is paid to the way in which Hobbes's text was assimilated to a moral and political position that combined (...) quasi‐Stoic moralism with fervent Royalism. (shrink)